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Lions vs. Steelers Week 16 Predictions, Odds and Stats

Detroit Lions v Los Angeles Rams - NFL 2025

Photo: Harry How / Getty Images Sport / Getty Images

When the Detroit Lions match up with the Pittsburgh Steelers at 4:25 p.m. ET on Sunday, Dec. 21, our computer model predicts the Lions will win the game. Our model also projects the spead, point total, and final score, which you can read below.

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Lions vs. Steelers Game Info and TV Channel

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Lions vs. Steelers Odds and Betting Info

  • Spread favorite: Lions (-6.5)
  • Moneyline: Lions (-329), Steelers (+263)
  • Total: 52 points

Lions vs. Steelers Prediction

  • Pick ATS: Lions (-6.5)
  • Pick OU: Under (52)

Prediction:

Lions 29 - Steelers 22

    Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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    Lions vs. Steelers Betting Insights

    • The Lions have covered seven times in 14 games with a spread this season.
    • The Steelers are 7-7-0 ATS this season.
    • Detroit has an ATS record of 4-2 when playing as at least 6.5-point favorites this season.
    • Lions games have hit the over nine out of 14 times this season.
    • In 2025, eight Steelers games have gone over the point total.

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