George Kittle Week 16 Preview vs. the Colts

San Francisco 49ers receiver George Kittle has a good matchup in Week 16 (Monday at 8:15 p.m. ET), playing the Indianapolis Colts. The Colts are giving up the second-most passing yards in the league, 247.6 per game.

Kittle's 54 targets have led to 45 catches for 484 yards (and an average of 53.8 per game) and six scores.

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Kittle vs. the Colts

• Kittle vs the Colts (since 2021): 1 GP / 83 REC YPG / 1 REC TD
• Indianapolis has allowed six opposing receivers to rack up 100 or more receiving yards in a game in the 2025 season.
• The Colts have allowed 18 opposing players to record a TD reception against them this year.
• No player has registered more than one TD reception against Indianapolis on the season.
• Kittle will play against the NFL's 31st-ranked pass defense this week. The Colts concede 247.6 passing yards per game.
• Opponents of the Colts have totaled 18 touchdowns through the air (1.3 per game). The Colts' defense is ninth in the NFL in that category.

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Kittle Receiving Insights

• In the receiving game, Kittle has gone over on his receiving yards prop bet in 55.6% of his games (five of nine).
• Kittle has 11.2% of his team's target share (54 targets on 480 passing attempts).
• He has 484 receiving yards on 54 targets to rank 25th in league play with 9.0 yards per target.
• Kittle has had a touchdown catch in five of nine games this season, and he found the end zone more than once on one of those occasions.
• He has scored six of his team's 37 offensive touchdowns this season (16.2%).
• Kittle has been targeted 10 times in the red zone (12.8% of his team's 78 red zone pass attempts).

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Kittle's Recent Performance