49ers vs. Colts Dec. 22 Viewing Options: TV, Live Stream

When the Indianapolis Colts (8-6) host the San Francisco 49ers (10-4) on Monday, December 22, 2025 at Lucas Oil Stadium, they will aim to break a four-game losing streak.

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49ers vs. Colts: Dec. 22 Viewing Options

• When: Monday, December 22, 2025 at 8:15 p.m. ET
• Where: Lucas Oil Stadium in Indianapolis, Indiana
• TV: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Listen to the game on 107.5 The Fan

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49ers vs. Colts Insights

• The 49ers, on average, are scoring three more points per game this season (24.6) than the Colts are allowing (21.6).
• The Colts have put an average of 28 points per game on the board this year, 7.1 more than the 20.9 the 49ers have surrendered.
• The total number of yards San Francisco's offense has put up and Indianapolis' defense has given up per game this season is within 4.8 yards (347.5 compared to 342.7). San Francisco averages 5.5 yards per play, while Indianapolis gives up 5.5.
• San Francisco's defense has given up 333.6 yards per game this year, 24.3 yards less than the 357.9-yard average from Indianapolis' offense. Indianapolis gains 6.2 yards per play and San Francisco gives up 5.7.
• The Colts' defense has given up an average of 95.1 yards per game to opposing running games this season. That total is about the same as the rushing output per contest for the 49ers (101.4 yards per game).
• The 49ers are conceding 106.1 yards per game on the ground, compared to the 128.9 rushing yards the Colts are accumulating.
• This season Indianapolis has forced 18 turnovers, compared to the 19 times San Francisco has turned the ball over.
• This year San Francisco has forced 14 turnovers, compared to the 16 times Indianapolis has turned the ball over.

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49ers' Upcoming Schedule

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Colts' Upcoming Schedule