Isaiah Williams Week 18 Preview vs. the Bills

Isaiah Williams will be running routes against the best passing defense in the NFL when his New York Jets play the Buffalo Bills in Week 18, on Sunday at 4:25 p.m. ET.

Williams has 169 yards on 21 receptions. He has been targeted 29 times, and posts 13.0 yards receiving per contest.

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Williams vs. the Bills

• Williams vs the Bills (since 2021): 1 GP / 0 REC YPG / 0 REC TD
• Buffalo has allowed 100 or more receiving yards to just three opposing receivers in the 2025 season.
• 17 players have grabbed a TD pass against the Bills this year.
• Just one opposing player has caught at least two TD passes in matchups with Buffalo on the season.
• The pass defense of the Bills is conceding 163.4 yards per outing this season, which ranks first in the league.
• So far this season, the Bills have surrendered 18 passing TDs to opponents, averaging 1.1 per game. That ranks fourth in league play.

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Williams Receiving Insights

• In the receiving game, Williams has hit the over on his receiving yards prop bet in 60.0% of his games (three of five).
• Williams has been targeted on 29 of his team's 472 passing attempts this season (6.1% target share).
• He has picked up 5.8 yards per target (169 yards on 29 targets).
• Williams, in eight games this season, has zero TD receptions.
• He has 8.0% of his team's 25 offensive touchdowns this season (two).

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Williams' Recent Performance